A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo

• मुख्य लेखकों: Yi-Wen Wu (लेखक), Kai-Cheng Hsu (लेखक), Hsueh-Yun Lee (लेखक), Tsui-Chin Huang (लेखक), Tony E. Lin (लेखक), Yi-Ling Chen (लेखक), Ting-Yi Sung (लेखक), Jing-Ping Liou (लेखक), Wendy W. Hwang-Verslues (लेखक), Shiow-Lin Pan (लेखक), Wei-Chun HuangFu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The combination cancer therapy is a new strategy to circumvent drug resistance for the treatment of high metastasis and advanced malignancies. Herein, we developed a synthesized compound MPT0B451 that display inhibitory effect against histone deacetylase (HDAC) 6 and tubulin assembly. Our data demon...