Advanced Resistance Studies Identify Two Discrete Mechanisms in <i>Staphylococcus aureus</i> to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

• Main Authors: Andrew J. Hayes (Author), Jiulia Satiaputra (Author), Louise M. Sternicki (Author), Ashleigh S. Paparella (Author), Zikai Feng (Author), Kwang J. Lee (Author), Beatriz Blanco-Rodriguez (Author), William Tieu (Author), Bart A. Eijkelkamp (Author), Keith E. Shearwin (Author), Tara L. Pukala (Author), Andrew D. Abell (Author), Grant W. Booker (Author), Steven W. Polyak (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant <i>Staphylococcus aureus</i> (<i>S. aureus</i>). In <i>S. aureus,</i> BPL is a bifunctional protein responsible for enzymatic biotinyla...