Numerical simulation method for the assessment of the effect of molar activity on the pharmacokinetics of radioligands in small animals

• Main Authors: Tatsuya Kikuchi (Author), Toshimitsu Okamura (Author), Ming-Rong Zhang (Author)
• Formato: Libro
• Publicado: SpringerOpen, 2024-11-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Abstract Background It is well recognized that the molar activity of a radioligand is an important pharmacokinetic parameter, especially in positron emission tomography (PET) of small animals. Occupation of a significant number of binding sites by radioligand molecules results in low radioligand acc...