Novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives as dual-action hypoglycemic agents that activate GK and PPARγ

• 主要な著者: Hui-peng Song (著者), Kang Tian (著者), Lei Lei (著者), Zhu-fang Shen (著者), Shou-xin Liu (著者), Li-juan Zhang (著者), Hong-rui Song (著者), Xiao-feng Jin (著者), Zhi-qiang Feng (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2011-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

A series of novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives have been synthesized and evaluated as glucokinase (GK) activators. Ethyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl-amino)thiazole-5-carboxylate was found to be a potent dual-acting hypoglycemic agent activating bot...