Novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives as dual-action hypoglycemic agents that activate GK and PPARγ

• Những tác giả chính: Hui-peng Song (Tác giả), Kang Tian (Tác giả), Lei Lei (Tác giả), Zhu-fang Shen (Tác giả), Shou-xin Liu (Tác giả), Li-juan Zhang (Tác giả), Hong-rui Song (Tác giả), Xiao-feng Jin (Tác giả), Zhi-qiang Feng (Tác giả)
• Định dạng: Sách
• Được phát hành: Elsevier, 2011-10-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

A series of novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives have been synthesized and evaluated as glucokinase (GK) activators. Ethyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl-amino)thiazole-5-carboxylate was found to be a potent dual-acting hypoglycemic agent activating bot...