Novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives as dual-action hypoglycemic agents that activate GK and PPARγ

• Main Authors: Hui-peng Song (Author), Kang Tian (Author), Lei Lei (Author), Zhu-fang Shen (Author), Shou-xin Liu (Author), Li-juan Zhang (Author), Hong-rui Song (Author), Xiao-feng Jin (Author), Zhi-qiang Feng (Author)
• Format: Book
• Published: Elsevier, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives have been synthesized and evaluated as glucokinase (GK) activators. Ethyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl-amino)thiazole-5-carboxylate was found to be a potent dual-acting hypoglycemic agent activating bot...