Novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives as dual-action hypoglycemic agents that activate GK and PPARγ

• Главные авторы: Hui-peng Song (Автор), Kang Tian (Автор), Lei Lei (Автор), Zhu-fang Shen (Автор), Shou-xin Liu (Автор), Li-juan Zhang (Автор), Hong-rui Song (Автор), Xiao-feng Jin (Автор), Zhi-qiang Feng (Автор)
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• Опубликовано: Elsevier, 2011-10-01T00:00:00Z.
• Предметы: article
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A series of novel N-(pyrimidin-4-yl)thiazol-2-amine derivatives have been synthesized and evaluated as glucokinase (GK) activators. Ethyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl-amino)thiazole-5-carboxylate was found to be a potent dual-acting hypoglycemic agent activating bot...