Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN

• Main Authors: Weilian Liang (Author), Yang Chen (Author), Hanzhe Liu (Author), Hui Zhao (Author), Tingting Luo (Author), Hokeung Tang (Author), Xiaocheng Zhou (Author), Erhui Jiang (Author), Zhe Shao (Author), Ke Liu (Author), Zhengjun Shang (Author)
• Format: Book
• Published: Nature Publishing Group, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tumor volume increases continuously in the advanced stage, and aside from the self-renewal of tumor cells, whether the oncogenic transformation of surrounding normal cells is involved in this process is currently unclear. Here, we show that oral squamous cell carcinoma (OSCC)-derived small...