Baicalin circumvents anti-PD-1 resistance by regulating the gut microbiota metabolite short-chain fatty acids

• Main Authors: Zhang Yu (Author), Liu Xiaojia (Author), Zhao Wei (Author), Zhang Jian (Author), Wang Aiting (Author), Wang Jing (Author), Yang Lin (Author), Cao Bangwei (Author), Yan Dan (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Baicalin is a small molecule medication used to treat hepatitis. Our research group discovered that administering baicalin orally to mice following fecal microbiota transplantation from patients resistant to ICIs supported anti-PD-1 activity. However, the precise mechanisms behind this effect are pr...