Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects

• প্রধান লেখক: Wei Wei (লেখক), Qingxuan Zeng (লেখক), Yan Wang (লেখক), Xixi Guo (লেখক), Tianyun Fan (লেখক), Yinghong Li (লেখক), Hongbin Deng (লেখক), Liping Zhao (লেখক), Xintong Zhang (লেখক), Yonghua Liu (লেখক), Yulong Shi (লেখক), Jingyang Zhu (লেখক), Xican Ma (লেখক), Yanxiang Wang (লেখক), Jiandong Jiang (লেখক), Danqing Song (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2023-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Using chemoproteomic techniques, we first identified EIF2AK2, eEF1A1, PRDX3 and VPS4B as direct targets of berberine (BBR) for its synergistically anti-inflammatory effects. Of them, BBR has the strongest affinity with EIF2AK2 via two ionic bonds, and regulates several key inflammatory pathways thro...