An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary dilated cardiomyopathy: genetics and bioinfomatics exploration

• Main Authors: Lei Chang (Author), Rong Huang (Author), Jianzhou Chen (Author), Guannan Li (Author), Guangfei Shi (Author), Biao Xu (Author), Lian Wang (Author)
• Formato: Livro
• Publicado em: BMC, 2023-10-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract LMNA gene encodes lamin A/C protein which participates in the construction of nuclear lamina, the mutations of LMNA result in a wide variety of diseases known as laminopathies. LMNA-related dilated cardiomyopathy(LMNA-DCM) is one of the more common laminopathy which characterized by progres...