In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions

• मुख्य लेखकों: Parthena Martin (लेखक), Maciej Czerwiński (लेखक), Pallavi B. Limaye (लेखक), Seema Muranjan (लेखक), Brian W. Ogilvie (लेखक), Steven Smith (लेखक), Brooks Boyd (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2022-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Fenfluramine (FFA) has potent antiseizure activity in severe, pharmacoresistant childhood‐onset developmental and epileptic encephalopathies (e.g., Dravet syndrome). To assess risk of drug interaction affecting pharmacokinetics of FFA and its major metabolite, norfenfluramine (nFFA), we con...