In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions

• Main Authors: Parthena Martin (Author), Maciej Czerwiński (Author), Pallavi B. Limaye (Author), Seema Muranjan (Author), Brian W. Ogilvie (Author), Steven Smith (Author), Brooks Boyd (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Fenfluramine (FFA) has potent antiseizure activity in severe, pharmacoresistant childhood‐onset developmental and epileptic encephalopathies (e.g., Dravet syndrome). To assess risk of drug interaction affecting pharmacokinetics of FFA and its major metabolite, norfenfluramine (nFFA), we con...