Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity

Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity

Objective: In mouse models, deficiency of TTC39B (T39) decreases hepatic lipogenic gene expression and protects against diet-induced steatohepatitis. While assessing the therapeutic potential of antisense oligonucleotides (ASOs) targeting T39, we discovered an unexpected weight loss phenotype. The o...

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Main Authors: Kristin M. McCabe (Author), Joanne Hsieh (Author), David G. Thomas (Author), Matthew M. Molusky (Author), Liana Tascau (Author), Jun B. Feranil (Author), Li Qiang (Author), Anthony W. Ferrante, Jr (Author), Alan R. Tall (Author)
Format: Book
Published: Elsevier, 2020-04-01T00:00:00Z.
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3rd Floor Main Library

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