Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity

• প্রধান লেখক: Kristin M. McCabe (লেখক), Joanne Hsieh (লেখক), David G. Thomas (লেখক), Matthew M. Molusky (লেখক), Liana Tascau (লেখক), Jun B. Feranil (লেখক), Li Qiang (লেখক), Anthony W. Ferrante, Jr (লেখক), Alan R. Tall (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2020-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objective: In mouse models, deficiency of TTC39B (T39) decreases hepatic lipogenic gene expression and protects against diet-induced steatohepatitis. While assessing the therapeutic potential of antisense oligonucleotides (ASOs) targeting T39, we discovered an unexpected weight loss phenotype. The o...