Antisense oligonucleotide treatment produces a type I interferon response that protects against diet-induced obesity

• Päätekijät: Kristin M. McCabe (Tekijä), Joanne Hsieh (Tekijä), David G. Thomas (Tekijä), Matthew M. Molusky (Tekijä), Liana Tascau (Tekijä), Jun B. Feranil (Tekijä), Li Qiang (Tekijä), Anthony W. Ferrante, Jr (Tekijä), Alan R. Tall (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2020-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Objective: In mouse models, deficiency of TTC39B (T39) decreases hepatic lipogenic gene expression and protects against diet-induced steatohepatitis. While assessing the therapeutic potential of antisense oligonucleotides (ASOs) targeting T39, we discovered an unexpected weight loss phenotype. The o...