JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice

• Main Authors: Daisuke Tomimoto (Author), Chihiro Okuma (Author), Yukihito Ishii (Author), Akio Kobayashi (Author), Takeshi Ohta (Author), Makoto Kakutani (Author), Tsuneo Imanaka (Author), Nobuya Ogawa (Author)
• Format: Book
• Published: Elsevier, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Type 2 diabetes mellitus (T2DM) arises primarily due to lifestyle factors and genetics. A number of lifestyle factors are known to be important in the development of T2DM, including obesity. JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase 1 inhibitor, reduced body weight depending on dietar...