Sesamol Attenuates Renal Inflammation and Arrests Reactive-Oxygen-Species-Mediated IL-1β Secretion via the HO-1-Induced Inhibition of the IKKα/NFκB Pathway In Vivo and In Vitro

• Hauptverfasser: Kuo-Feng Tseng (Verfasst von), Ping-Hsuan Tsai (Verfasst von), Jie-Sian Wang (Verfasst von), Fang-Yu Chen (Verfasst von), Ming-Yi Shen (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Chronic nephritis leads to irreversible renal fibrosis, ultimately leading to chronic kidney disease (CKD) and death. Macrophage infiltration and interleukin 1β (IL-1β) upregulation are involved in inflammation-mediated renal fibrosis and CKD. Sesamol (SM), which is extracted from sesame seeds, has...