Sesamol Attenuates Renal Inflammation and Arrests Reactive-Oxygen-Species-Mediated IL-1β Secretion via the HO-1-Induced Inhibition of the IKKα/NFκB Pathway In Vivo and In Vitro

• Päätekijät: Kuo-Feng Tseng (Tekijä), Ping-Hsuan Tsai (Tekijä), Jie-Sian Wang (Tekijä), Fang-Yu Chen (Tekijä), Ming-Yi Shen (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Chronic nephritis leads to irreversible renal fibrosis, ultimately leading to chronic kidney disease (CKD) and death. Macrophage infiltration and interleukin 1β (IL-1β) upregulation are involved in inflammation-mediated renal fibrosis and CKD. Sesamol (SM), which is extracted from sesame seeds, has...