Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca2+ release

• Main Authors: Thomas E. Jensen (Author), Lykke Sylow (Author), Adam J. Rose (Author), Agnete B. Madsen (Author), Yeliz Angin (Author), Stine J. Maarbjerg (Author), Erik A. Richter (Author)
• Format: Book
• Published: Elsevier, 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Understanding how muscle contraction orchestrates insulin-independent muscle glucose transport may enable development of hyperglycemia-treating drugs. The prevailing concept implicates Ca2+ as a key feed forward regulator of glucose transport with secondary fine-tuning by metabolic feedback signals...