Effects of a Serine Protease Inhibitor N-<i>p</i>-Tosyl-L-phenylalanine Chloromethyl Ketone (TPCK) on <i>Leishmania amazonensis</i> and <i>Leishmania infantum</i>

• Váldodahkkit: Patrícia de A. Machado (Dahkki), Pollyanna S. Gomes (Dahkki), Monique P. D. Carneiro (Dahkki), Victor Midlej (Dahkki), Elaine S. Coimbra (Dahkki), Herbert L. de Matos Guedes (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Studies have previously demonstrated the importance of serine proteases in <i>Leishmania</i>. A well-known serine protease inhibitor, TPCK, was used in the present study to evaluate its in vitro and in vivo antileishmanial effects and determine its mechanism of action. Despite slight tox...