Effects of a Serine Protease Inhibitor N-<i>p</i>-Tosyl-L-phenylalanine Chloromethyl Ketone (TPCK) on <i>Leishmania amazonensis</i> and <i>Leishmania infantum</i>

• Autori principali: Patrícia de A. Machado (Autore), Pollyanna S. Gomes (Autore), Monique P. D. Carneiro (Autore), Victor Midlej (Autore), Elaine S. Coimbra (Autore), Herbert L. de Matos Guedes (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2022-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Studies have previously demonstrated the importance of serine proteases in <i>Leishmania</i>. A well-known serine protease inhibitor, TPCK, was used in the present study to evaluate its in vitro and in vivo antileishmanial effects and determine its mechanism of action. Despite slight tox...