Effects of a Serine Protease Inhibitor N-<i>p</i>-Tosyl-L-phenylalanine Chloromethyl Ketone (TPCK) on <i>Leishmania amazonensis</i> and <i>Leishmania infantum</i>

• Hauptverfasser: Patrícia de A. Machado (Verfasst von), Pollyanna S. Gomes (Verfasst von), Monique P. D. Carneiro (Verfasst von), Victor Midlej (Verfasst von), Elaine S. Coimbra (Verfasst von), Herbert L. de Matos Guedes (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-06-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Studies have previously demonstrated the importance of serine proteases in <i>Leishmania</i>. A well-known serine protease inhibitor, TPCK, was used in the present study to evaluate its in vitro and in vivo antileishmanial effects and determine its mechanism of action. Despite slight tox...