TGF-β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway

• Autores principales: Lanlan Fang (Autor), Yang Yan (Autor), Yibo Gao (Autor), Ze Wu (Autor), Zhen Wang (Autor), Sizhu Yang (Autor), Jung-Chien Cheng (Autor), Ying-Pu Sun (Autor)
• Formato: Libro
• Publicado: BMC, 2022-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background Tightly regulation of extravillous cytotrophoblast (EVT) cell invasion is critical for the placentation and establishment of a successful pregnancy. Insufficient EVT cell invasion leads to the development of preeclampsia (PE) which is a leading cause of maternal and perinatal mor...