TGF-β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway

• Main Authors: Lanlan Fang (Author), Yang Yan (Author), Yibo Gao (Author), Ze Wu (Author), Zhen Wang (Author), Sizhu Yang (Author), Jung-Chien Cheng (Author), Ying-Pu Sun (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Tightly regulation of extravillous cytotrophoblast (EVT) cell invasion is critical for the placentation and establishment of a successful pregnancy. Insufficient EVT cell invasion leads to the development of preeclampsia (PE) which is a leading cause of maternal and perinatal mor...