Identification of novel LEPR mutations in Pakistani families with morbid childhood obesity

• Main Authors: Robina Khan Niazi (Author), Anette P Gjesing (Author), Mette Hollensted (Author), Christian Theil Have (Author), Niels Grarup (Author), Oluf Pedersen (Author), Asmat Ullah (Author), Gulbin Shahid (Author), Wasim Ahmad (Author), Asma Gul (Author), Torben Hansen (Author)
• Format: Book
• Published: BMC, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mutations in the genes encoding leptin (LEP), the leptin receptor (LEPR), and the melanocortin 4 receptor (MC4R) are known to cause severe early-onset childhood obesity. The aim of the current study was to examine the prevalence of damaging LEP, LEPR, and MC4R mutations in Pakist...