New personalized genetic mouse model of Lesch-Nyhan syndrome for pharmacology and gene therapy

• Main Authors: Vladislav Kalmykov (Author), Pavel Kusov (Author), Maria Yablonskaia (Author), Evgeniy Korshunov (Author), Diana Korshunova (Author), Marina Kubekina (Author), Yuliya Silaeva (Author), Alexey Deykin (Author), Nikolay Lukyanov (Author)
• Format: Book
• Published: Belgorod National Research University, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Lesch-Nyhan syndrome is a clinical and laboratory disorder caused by X-linked disruption of the purine metabolism. The deletion in the HPRT1 gene leads to the disappearance of valine in the eighth position of the protein amino acid sequence. The disease occurs in males and is accompani...