New personalized genetic mouse model of Lesch-Nyhan syndrome for pharmacology and gene therapy

• Главные авторы: Vladislav Kalmykov (Автор), Pavel Kusov (Автор), Maria Yablonskaia (Автор), Evgeniy Korshunov (Автор), Diana Korshunova (Автор), Marina Kubekina (Автор), Yuliya Silaeva (Автор), Alexey Deykin (Автор), Nikolay Lukyanov (Автор)
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• Опубликовано: Belgorod National Research University, 2018-12-01T00:00:00Z.
• Предметы: article
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Introduction: Lesch-Nyhan syndrome is a clinical and laboratory disorder caused by X-linked disruption of the purine metabolism. The deletion in the HPRT1 gene leads to the disappearance of valine in the eighth position of the protein amino acid sequence. The disease occurs in males and is accompani...