The emerging role of irisin in experimentally induced arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase I-mediated necroptosis

• Main Authors: Rowida Raafat Ibrahim (Author), Noha M. Shafik (Author), Rasha Osama El-Esawy (Author), Mervat H. El-Sakaa (Author), Heba M. Arakeeb (Author), Radwa Mahmoud El-Sharaby (Author), Dina Adam Ali (Author), Omnia Safwat El-deeb (Author), Sara Ragab Abd El-Khalik (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives Necroptosis is a tightly adjusted inflammatory necrotizing cell death signaling pathway that participates in pathogenesis of discrete diseases as rheumatoid arthritis (RA). Irisin is a myokine with immuno-modulatory effect. Evaluation of irisin efficiency as a novel therapeutic agent in e...