Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.

• المؤلفون الرئيسيون: María Ailén Natale (مؤلف), Todd Minning (مؤلف), María Cecilia Albareda (مؤلف), Melisa Daiana Castro Eiro (مؤلف), María Gabriela Álvarez (مؤلف), Bruno Lococo (مؤلف), Gonzalo Cesar (مؤلف), Graciela Bertocchi (مؤلف), María Josefina Elias (مؤلف), María Belén Caputo (مؤلف), Rick Lee Tarleton (مؤلف), Susana Adriana Laucella (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...