Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.

• 主要な著者: María Ailén Natale (著者), Todd Minning (著者), María Cecilia Albareda (著者), Melisa Daiana Castro Eiro (著者), María Gabriela Álvarez (著者), Bruno Lococo (著者), Gonzalo Cesar (著者), Graciela Bertocchi (著者), María Josefina Elias (著者), María Belén Caputo (著者), Rick Lee Tarleton (著者), Susana Adriana Laucella (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2021-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...