The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development

• Главные авторы: Marit Keuper-Navis (Автор), Markus Walles (Автор), Birk Poller (Автор), Adam Myszczyszyn (Автор), Thomas K. van der Made (Автор), Joanne Donkers (Автор), Hossein Eslami Amirabadi (Автор), Martijn J. Wilmer (Автор), Saskia Aan (Автор), Bart Spee (Автор), Rosalinde Masereeuw (Автор), Evita van de Steeg (Автор)
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• Опубликовано: Elsevier, 2023-09-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review, the potential of OoC models to improve the prediction of human oral bioavailability and intrinsic clearance is discussed, with a focus on the fu...