The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development

• Main Authors: Marit Keuper-Navis (Author), Markus Walles (Author), Birk Poller (Author), Adam Myszczyszyn (Author), Thomas K. van der Made (Author), Joanne Donkers (Author), Hossein Eslami Amirabadi (Author), Martijn J. Wilmer (Author), Saskia Aan (Author), Bart Spee (Author), Rosalinde Masereeuw (Author), Evita van de Steeg (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review, the potential of OoC models to improve the prediction of human oral bioavailability and intrinsic clearance is discussed, with a focus on the fu...