In Vitro PIG-A Gene Mutation Assay in Human B-Lymphoblastoid TK6 Cells

• Principais autores: Chang-Hui Zhou (Autor), Chun-Rong Yu (Autor), Peng-Cheng Huang (Autor), Ruo-Wan Li (Autor), Jing-Ting Wang (Autor), Tian-Tian Zhao (Autor), Ze-Hao Zhao (Autor), Jing Ma (Autor), Yan Chang (Autor)
• Formato: Livro
• Publicado em: Georg Thieme Verlag KG, 2021-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The X-linked PIG-A gene is involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. PIG-A mutant cells fail to synthesize GPI and to express GPI-anchored protein markers (e.g., CD59 and CD55). In recent years, in vitro PIG-A assay has been established based on the high conservatio...