Engineering T cells with hypoxia-inducible chimeric antigen receptor (HiCAR) for selective tumor killing

Abstract Chimeric antigen receptor-modified T cells (CAR-T cells) have shown good effects in the treatment of hematologic cancers; however, they may cause on-target off-tumor toxicity because of minimal expression of tumor-associated antigens (TAAs) on normal tissues, particularly in the context of...

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Main Authors: Qibin Liao (Author), Huan He (Author), Yunyu Mao (Author), Xiangqing Ding (Author), Xiaoyan Zhang (Author), Jianqing Xu (Author)
Format: Book
Published: BMC, 2020-10-01T00:00:00Z.
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3rd Floor Main Library

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