Engineering T cells with hypoxia-inducible chimeric antigen receptor (HiCAR) for selective tumor killing

• Auteurs principaux: Qibin Liao (Auteur), Huan He (Auteur), Yunyu Mao (Auteur), Xiangqing Ding (Auteur), Xiaoyan Zhang (Auteur), Jianqing Xu (Auteur)
• Format: Livre
• Publié: BMC, 2020-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Chimeric antigen receptor-modified T cells (CAR-T cells) have shown good effects in the treatment of hematologic cancers; however, they may cause on-target off-tumor toxicity because of minimal expression of tumor-associated antigens (TAAs) on normal tissues, particularly in the context of...