Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs

• Main Authors: Min Li (Author), Yasunari Kanda (Author), Takashi Ashihara (Author), Tetsuo Sasano (Author), Yuji Nakai (Author), Masami Kodama (Author), Erina Hayashi (Author), Yuko Sekino (Author), Tetsushi Furukawa (Author), Junko Kurokawa (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature functional and structural characteristics, including spontaneous activity. Our p...