Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs

• Váldodahkkit: Min Li (Dahkki), Yasunari Kanda (Dahkki), Takashi Ashihara (Dahkki), Tetsuo Sasano (Dahkki), Yuji Nakai (Dahkki), Masami Kodama (Dahkki), Erina Hayashi (Dahkki), Yuko Sekino (Dahkki), Tetsushi Furukawa (Dahkki), Junko Kurokawa (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2017-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature functional and structural characteristics, including spontaneous activity. Our p...