Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer

• Váldodahkkit: Xiaomin Wang (Dahkki), Jun Xu (Dahkki), Yiming Sun (Dahkki), Siyuwei Cao (Dahkki), Hanlin Zeng (Dahkki), Nan Jin (Dahkki), Matthew Shou (Dahkki), Shuai Tang (Dahkki), Yi Chen (Dahkki), Min Huang (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2023-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Epigenetic therapies that cause genome-wide epigenetic alterations, could trigger local interplay between different histone marks, leading to a switch of transcriptional outcome and therapeutic responses of epigenetic treatment. However, in human cancers with diverse oncogenic activation, how oncoge...