Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer

• Main Authors: Xiaomin Wang (Author), Jun Xu (Author), Yiming Sun (Author), Siyuwei Cao (Author), Hanlin Zeng (Author), Nan Jin (Author), Matthew Shou (Author), Shuai Tang (Author), Yi Chen (Author), Min Huang (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epigenetic therapies that cause genome-wide epigenetic alterations, could trigger local interplay between different histone marks, leading to a switch of transcriptional outcome and therapeutic responses of epigenetic treatment. However, in human cancers with diverse oncogenic activation, how oncoge...