Scaling up for the industrial production of rifamycin B; optimization of the process conditions in bench-scale fermentor

• Main Authors: Hewaida F. El-Sedawy (Author), Manal M.M. Hussein (Author), Tamer Essam (Author), Ossama M. El-Tayeb (Author), Fatma H.A. Mohammad (Author)
• Format: Book
• Published: Faculty of Pharmacy, Cairo University, 2013-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Optimization of fermentation process conditions using a gene amplified variant of Amycolatopsis mediterranei (NCH) was carried out. The use of aeration level 1.5 vvm increased the yield by 16.6% (from 13.81 to 16.1 g/l) upon controlling the temperature at 28 °C. Adjustment of the aeration level at 1...