Joint use of population pharmacokinetics and machine learning for optimizing antiepileptic treatment in pediatric population

• Main Authors: Ivana Damnjanović (Author), Nastia Tsyplakova (Author), Nikola Stefanović (Author), Tatjana Tošić (Author), Aleksandra Catić-Đorđević (Author), Vangelis Karalis (Author)
• Format: Book
• Published: SAGE Publishing, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Unpredictable drug efficacy and safety of combined antiepileptic therapy is a major challenge during pharmacotherapy decisions in everyday clinical practice. The aim of this study was to describe the pharmacokinetics of valproic acid (VA), lamotrigine (LTG), and levetiracetam (LEV) in a ped...