Joint use of population pharmacokinetics and machine learning for optimizing antiepileptic treatment in pediatric population

• Päätekijät: Ivana Damnjanović (Tekijä), Nastia Tsyplakova (Tekijä), Nikola Stefanović (Tekijä), Tatjana Tošić (Tekijä), Aleksandra Catić-Đorđević (Tekijä), Vangelis Karalis (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: SAGE Publishing, 2023-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Purpose: Unpredictable drug efficacy and safety of combined antiepileptic therapy is a major challenge during pharmacotherapy decisions in everyday clinical practice. The aim of this study was to describe the pharmacokinetics of valproic acid (VA), lamotrigine (LTG), and levetiracetam (LEV) in a ped...