Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy

• Asıl Yazarlar: Hua Zhang (Yazar), Tian Fu (Yazar), Jinglei Sun (Yazar), Sihao Zou (Yazar), Suhua Qiu (Yazar), Jiali Zhang (Yazar), Shi Su (Yazar), Chenxia Shi (Yazar), De-Pei Li (Yazar), Yanfang Xu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The human ether-á-go-go-related gene (hERG) encodes the pore-forming subunit (Kv11.1), conducting a rapidly delayed rectifier K+ current (IKr). Reduction of IKr in pathological cardiac hypertrophy (pCH) contributes to increased susceptibility to arrhythmias. However, practical approaches to prevent...