Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy

• Main Authors: Hua Zhang (Author), Tian Fu (Author), Jinglei Sun (Author), Sihao Zou (Author), Suhua Qiu (Author), Jiali Zhang (Author), Shi Su (Author), Chenxia Shi (Author), De-Pei Li (Author), Yanfang Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human ether-á-go-go-related gene (hERG) encodes the pore-forming subunit (Kv11.1), conducting a rapidly delayed rectifier K+ current (IKr). Reduction of IKr in pathological cardiac hypertrophy (pCH) contributes to increased susceptibility to arrhythmias. However, practical approaches to prevent...