2-(4-Methylthiazol-5-yl) Ethyl Nitrate Hydrochloride Ameliorates Cognitive Impairment via Modulation of Oxidative Stress and Nuclear Factor Kappa B (NF-κB) Signaling Pathway in Chronic Cerebral Hypoperfusion-Associated Spontaneously Hypertensive Rats

• Ngā kaituhi matua: Jiang Li (Author), Shaofeng Xu (Author), Ling Wang (Author), Xiaoliang Wang (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2024-05-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Hypertension reduces the bioavailability of vascular nitric oxide (NO) and contributes to the onset of vascular dementia (VaD). A loss of NO bioavailability increases inflammation and oxidative stress. 2-(4-Methylthiazol-5-yl) ethyl nitrate hydrochloride (W1302) is a novel nitric oxide donor (NOD) w...