Functional candesartan loaded lipid nanoparticles for the control of diabetes-associated stroke: In vitro and in vivo studies

• Main Authors: Dina M. Mahmoud (Author), Mohammed R.A. Ali (Author), Basmah Nasser Aldosari (Author), Randa Mohammed Zaki (Author), Obaid Afzal (Author), Alaa S. Tulbah (Author), Demiana M. Naguib (Author), Mohamed I. Zanaty (Author), Mary Eskander Attia (Author), Fatma I. Abo El-Ela (Author), Amr Gamal Fouad (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetes mellitus is a metabolic disease that raises the odds of developing stroke. Candesartan has been used to prevent stroke due to its inhibitory effects on blood pressure, angiogenesis, oxidative damage, and apoptosis. However, oral candesartan has very limited bioavailability and efficacy due...