Synthesis and cytotoxicity evaluation of thiosemicarbazones and their thiazole derivatives

• Main Authors: Saulo Feheiberg Pinto Braga (Author), Nayara Cristina Fonseca (Author), Jonas Pereira Ramos (Author), Elaine Maria de Souza-Fagundes (Author), Renata Barbosa de Oliveira (Author)
• Format: Book
• Published: Universidade de São Paulo.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT The aims of this study were to synthesize a series of thiosemicarbazones and their thiazole derivatives, to investigate their cytotoxic activity against three human cancers and normal (Vero cells) cell lines, and to evaluate the pro-apoptotic potential of the most active compounds. Material...