Trimidox-Induced Apoptosis Is Mediated Through Induction of p53 in NALM-6 Cells

• Main Authors: Syu-ichi Kanno (Author), Takaharu Ohtake (Author), Yuu Osanai (Author), Kaori Kurauchi (Author), Mayuko Ujibe (Author), Koji Uwai (Author), Mituhiro Takeshita (Author), Susumu Satoh (Author), Masaaki Ishikawa (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the effect of trimidox-induced apoptosis involvement of p53 in the NALM-6 cell line of acute lymphoblastic leukemia. Trimidox has been shown to increase the induction of p53. Phosphorylation of p53 protein at Ser-15 and Ser-20 residues was activated earlier than the obvious increase in p...