In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae

• Hauptverfasser: Wan Yean Chung (Verfasst von), Nusaibah Abdul Rahim (Verfasst von), Mohd Hafidz Mahamad Maifiah (Verfasst von), Naveen Kumar Hawala Shivashekaregowda (Verfasst von), Yan Zhu (Verfasst von), Eng Hwa Wong (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Schlagworte: article
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Multidrug-resistant (MDR) Klebsiella pneumoniae is a top-prioritized Gram-negative pathogen with a high incidence in hospital-acquired infections. Polymyxins have resurged as a last-line therapy to combat Gram-negative "superbugs", including MDR K. pneumoniae. However, the emergence of pol...