In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae

• Main Authors: Wan Yean Chung (Author), Nusaibah Abdul Rahim (Author), Mohd Hafidz Mahamad Maifiah (Author), Naveen Kumar Hawala Shivashekaregowda (Author), Yan Zhu (Author), Eng Hwa Wong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug-resistant (MDR) Klebsiella pneumoniae is a top-prioritized Gram-negative pathogen with a high incidence in hospital-acquired infections. Polymyxins have resurged as a last-line therapy to combat Gram-negative "superbugs", including MDR K. pneumoniae. However, the emergence of pol...