In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae

• Váldodahkkit: Wan Yean Chung (Dahkki), Nusaibah Abdul Rahim (Dahkki), Mohd Hafidz Mahamad Maifiah (Dahkki), Naveen Kumar Hawala Shivashekaregowda (Dahkki), Yan Zhu (Dahkki), Eng Hwa Wong (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Multidrug-resistant (MDR) Klebsiella pneumoniae is a top-prioritized Gram-negative pathogen with a high incidence in hospital-acquired infections. Polymyxins have resurged as a last-line therapy to combat Gram-negative "superbugs", including MDR K. pneumoniae. However, the emergence of pol...