Natural statin derivatives as potential therapy to reduce intestinal fluid loss in cholera.

• Main Authors: Rattikarn Noitem (Author), Pawin Pongkorpsakol (Author), Chartchai Changsen (Author), Yaowapa Sukpondma (Author), Chittreeya Tansakul (Author), Vatcharin Rukachaisirikul (Author), Chatchai Muanprasat (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a leading cause of death in children under 5 years old, secretory diarrheas including cholera are characterized by excessive intestinal fluid secretion driven by enterotoxin-induced cAMP-dependent intestinal chloride transport. This study aimed to identify fungal bioactive metabolites possessing...