Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH1 to TH2 Phenotypes During Disease Progression

• Main Authors: Naxin Sun (Author), Guiwen Yang (Author), Heng Zhao (Author), Huub F. J. Savelkoul (Author), Liguo An (Author)
• Format: Book
• Published: Hindawi Limited, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrophages (Mp) are implicated in both early and late phases in type 1 diabetes development. Recent study has suggested that a balance between reductive Mp (RMp) and oxidative Mp (OMp) is possible to regulate TH1/TH2 balance. The aim of this study is to investigate the redox status of peritoneal Mp...