A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

• Главные авторы: Pedro Martín-Acosta (Автор), Qianli Meng (Автор), John Klimek (Автор), Ashok P. Reddy (Автор), Larry David (Автор), Stefanie Kaech Petrie (Автор), Bingbing X. Li (Автор), Xiangshu Xiao (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2022-05-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility. While it remains a challenge, unbiased chemoproteomics strategy using clickable photoaffinity probes is a useful and validated approac...