A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors

• Auteurs principaux: Shai Berlin (Auteur), Etay Artzy (Auteur), Reem Handklo-Jamal (Auteur), Uri Kahanovitch (Auteur), Hanna Parnas (Auteur), Nathan Dascal (Auteur), Daniel Yakubovich (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The G protein-activated Inwardly Rectifying K+-channel (GIRK) modulates heart rate and neuronal excitability. Following G-Protein Coupled Receptor (GPCR)-mediated activation of heterotrimeric G proteins (Gαβγ), opening of the channel is obtained by direct binding of Gβγ subunits. Interestingly, GIRK...