A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors

• Autores principales: Shai Berlin (Autor), Etay Artzy (Autor), Reem Handklo-Jamal (Autor), Uri Kahanovitch (Autor), Hanna Parnas (Autor), Nathan Dascal (Autor), Daniel Yakubovich (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The G protein-activated Inwardly Rectifying K+-channel (GIRK) modulates heart rate and neuronal excitability. Following G-Protein Coupled Receptor (GPCR)-mediated activation of heterotrimeric G proteins (Gαβγ), opening of the channel is obtained by direct binding of Gβγ subunits. Interestingly, GIRK...